Showing posts with label dna. Show all posts
Showing posts with label dna. Show all posts

Thursday, June 4, 2020

Bad to the Bone? (And Brain?)

There has been an ongoing debate among anthropologists whether human beings are inherently violent. Is violence in our nature or do the conditions in which we live groom us to become violent? Arguing for the nature side is 17th century philosopher Thomas Hobbes who was the first to speculate that the "natural condition of mankind" was one of violence and conflict. Arguing on the side of nurture is 18th century philosopher Jean-Jacques Rousseau who argued that it was civilization, not nature, that shaped the human proneness to violence. Both sound viable and perhaps both are. Let's dive in, shall we?

Primates first appeared about 55 million years ago. The world was a cruel, uncivilized, dangerous place and one had to mind oneself if they had any hopes of surviving. Mammals, such as primates, were territorial yet social animals; they lived with who they were familiar with and were not fond of outsiders. Outsiders meant less resources and sometimes less mates. To fend off outsiders, sharp canines would have to be bared (grrrr). By doing so, they were able to establish their dominance and keep competition for both resources and mates low. Reasoning with the outsider to leave and pose no threat to the community already there was not an option; but violence would surely do the trick. And so it came to be that ancient primates were some of the only mammals with a high rate of death among them (1.8%). Similarly, when the first prehistoric humans appeared about 7 million years ago, the rate of death among them due to lethal violence was 2%. This should not come as a surprise as humans ultimately evolved from primates which tend to come from a particularly violent mammalian clade.


Cladogram with darker lines representing the more violent species and the red triangle within Hominoidea representing humans. 

One of the many interesting things that both humans and primates have in common is the MAOA gene (aka warrior gene). Monoamine oxidase A is an enzyme whose purpose is breaking down certain neurotransmitters involved in aggression, emotion, and cognition. A mutant variant of this gene (which produces little or no functional MAOA enzyme) may result in the individual expressing enhanced aggression. Scientists speculate that the gene emerged 25 million years ago, some 30 million years after the first primates emerged. And as it is found in both humans and primates, we can only conclude that it was likely a genetic adaptation that primates acquired and that was favored by natural selection as it was passed down all the way to the first humans some 18 million years later.

So, it's evident that we have genes in our DNA which can result in brutal and violent behavior. Violence was quite inevitable for the ancient primates as it was used for protection and what not. We, on the other hand, live in a modern society with sophisticated institutions and laws. Using lethal violence to solve mindless spats or otherwise is more often than not not used in our day and age. Yet it occasionally does come up. Are those that express it outliers in our society or are they simply showing us what human beings are made of (dum du da daaaaa!)?


 MAOA Gene in Riverdale?! 

Still, it is possible that Hobbes was incorrect and that we aren't an inherently violent species, after all. Even though lethal violence may be part of our evolutionary history, that doesn't necessarily mean that it is engraved in our DNA. Prehistoric people were known to have been violent as several excavation sites have revealed such as the one in Kenya known as Nataruk. This site depicts a massacre in which at least 27 people (men, women, and children) were brutally murdered. It's unlikely that the aggressors attacked for kicks and giggles but it is likely that they attacked those who they viewed as competitors for resources and living space. Thus, it may not have been a genetic component leading the aggressors to act this way but environmental pressures on survival.

The environment in which you grow up in can also affect the way you behave as an adult. Results from research conducted by NIJ (National Institute of Justice) revealed that "childhood abuse increased the risk of adulthood crime by promoting antisocial behavior during childhood and adolescence..." The environmental conditions that one lives in throughout ones life have a significant and in many cases detrimental effect on the way their brain functions. For example, through the use of MRI technology, doctors were able to identify changes in the brains of adults who had been victims of abuse or neglect in their childhood. The research depicted that adults who had been exposed to such strenuous conditions in their childhood had significant changes in certain brain regions (hippocampus, corpus callosum, cerebellum, and more) that deal with important functions such as balancing emotions and impulses. Furthermore, studies have shown that individuals who were abused or subjected to stressful conditions in their childhood and who have the mutant variant of the MAOA gene (double whammy) are more likely manipulate, exploit, violate the rights of others, and commit violent, criminal acts.


MAOA Variant + Childhood maltreatment study data 

On the nurture side of the argument, all I've been talking about is how aggression and abuse in early childhood can lead people in the wrong direction as adults. But what about poverty? Greg Acs, VP at the Income and Benefits Policy Center of the Urban Institute explains that the reason certain groups  are more prone to live in a state of poverty due to "historical, economic, social, and personal factors." These factors fuel the discrimination these groups must live with, the same discrimination that limits their work and advancement opportunities. Stress, such as the one people living in poverty experience, can have similar effects on a person's developing brain like abuse. Research has found that when a person lives in poverty, their brain's limbic system (which processes emotions and triggers emotional responses) constantly sends "fear and stress messages to the prefrontal cortex, which overloads its ability to solve problems, set goals, and complete tasks in the most efficient ways." This overworking of the limbic system and the overloading of the prefrontal cortex may be what is leading those living in poverty to act in irrational ways and commit unlawful acts. And while this can happen to anyone no matter their social class, those living in poverty live in a state of constant stress and pressure, have it much worse than the majority of the population. 

So what are your opinions? Does nurture have an effect on nature or does nature get the only say? Does the lethal violence expressed in our evolutionary history define us? Are we all inherently violent and simply choose to suppress those feelings because to express them would be looked incredulously upon? Or are the conditions in which we live the determining factors on who and how we turn out to be? Or, is it a mixture of the two (which I think it is lol)?

Thursday, June 2, 2016

Of Telomeres, Eternal Youth, and Lobsters

If you have taken AP Bio, you will know that when DNA replicates, a small piece is cut off of the end each time (see the following image to attempt to understand, they explain it far better than I could).



Now, as one can imagine, when a piece of DNA is being removed with each replication, the entire strand is going to be shortened more and more over time. DNA replicates hundreds of times in the human lifespan, and it’s pretty unhealthy to lose all that DNA, right?

That’s where telomeres come in. Telomeres are pieces of DNA that hang out on either end of the functioning strand and that do not code for anything at all in the cell’s genes. They’re essentially buffers for the DNA, as when the DNA is replicated, only the telomeres are removed.

Until time runs out. 

There are only so many telomeres — humans can have up to 15,000 base pairs (letters, if you will) in their telomeres. And DNA replication happens frequently. Sooner or later, everyone runs out. And many scientists believe this is a root cause of the human aging process.

Now meet the Lobster.
This guy doesn’t have any of our telomere problems — because he can regenerate his telomeres.

Lobsters possess a special enzyme called telomerase, which rebuilds their telomeres between divisions. This means that no matter how many times a cell divides, it’s nowhere closer to having its DNA destroyed. And the lobsters don’t get old. 

Throughout its life (which can be over 100 years!), a lobster maintains a pretty constant state. His skin (shell?) does not sag and his metabolism does not slow down. They are as youthful as ever, and scientists believe this is because of the benefits of telomerase. Lobsters will eventually die, usually because of predators, but sometimes because they just can't make shells big enough to fit in anymore, but their lives are very different because of this unusual enzyme. 

Now here's where it gets even wilder. Turns out humans have telomerase too -- in children's growth cells, and in cancer cells. Turns out the same enzyme that allows lobsters to stay young is killing millions of people. This weird pattern has generated some important questions: 

Could the lobster be the secret to eternal youth? Could it help us stop cancer?

We’re not sure yet, but these phenomena look pretty interesting nonetheless. Scientists are hoping that telomerase will help us fight cancer, improve skin graft treatment, and, of course, combat aging. Many are working with it right now, and I, personally, am very excited to see where it goes. 

If you want to find out more, check out the following: 
Dr. Joe Dispenza
Smithsonian Magazine


Wednesday, June 1, 2016

Understanding the Impacts of the Genetic Diversity of a Wider Range of Americans

I recently read a New York Times article titled, "Tales of African-American History Found in DNA," and felt that a new discovery made by team of geneticists from McGill detailed in the article was too important not to share. While African Americans' harsh transatlantic journey to the U.S. to become slaves and their later migration from the South to cities in the North in the 1900s are significant and understood pieces of history, African Americans' genetic variation that arose as a result of such migration has not been investigated....until now. 


The team of geneticists at McGill evaluated the DNA of thousands of African Americans in three different medical studies. They discovered that the ancestors of the average African-American today were 82.1 percent African, 16.7 percent European and 1.2 percent Native American. You might be asking yourself why such findings are important. Well, besides the historical impact this research has,  the information revealed about African Americans' health is extremely significant. The map of genetic diversity created "will show how genes influence their risk for various diseases," according to the McGill geneticists. Most known information about the relationship between genes and disease has been centered around those of European descent, but now the focus has been broadened. Already, scientists have found a potential drug for heart disease through a rare genetic mutation found in African-American woman. Thus, more information on African American genetic diversity leads to not only benefits for African Americans, but discoveries that may benefit all people.